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Celecoxib

Tonsils and Adenoid Removal

The Department of Anesthesiology at CHEO is conducting a study looking at the ability of a drug, Celecoxib, to reduce the amount of pain your child will have after his/her tonsils or tonsils and adenoids (T&A) are removed. Our previous studies at CHEO have shown a 70% chance your child will have moderate to severe pain following a tonsillectomy or T&A.

Normally, your child will be given pain medications, such as morphine, following this surgery. These medications work well but have some side effects, such as: nausea and vomiting, constipation, itchiness and excessive sleepiness. Based on studies with adults, Celecoxib, an anti-inflammatory medication similar to ibuprofen (Advil ®), has been shown to reduce pain and have fewer side effects than traditional medications given for this surgery. Here at CHEO, we routinely give celecoxib to children to manage their acute and chronic pain with good success. However, it has not been formally studied in Canadian children.

In this study, your child will still receive our usual medications for pain. In addition, they will have a 1 in 2 chance of receiving either Celecoxib or a placebo (sugar syrup). Our study will be looking at the effect of celecoxib in combination with our usual pain medications, on pain relief and quality of life after tonsillectomy or adenotonsillectomy. In Canada, Celecoxib has yet to be approved for use among children.
If you are interested in learning more about how this study can potentially benefit your child e-mail us at anesthesiaresearch@cheo.on.ca.

Please let the clinic clerk know if you do not wish to be contacted.

Thank you for your interest,

Dr. Kimmo Murto and his research team

More Information

Click Here to download the Informed Consent for those whose child is undergoing Pediatric Adenotonsillectomy (removal of tonsil and adenoids).

Click Here to download the Assent Form for 8-15 year olds for Pediatric Adenotonsillectomy (removal of tonsil and adenoids).

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