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Enoxaparin

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What is enoxaparin?

Enoxaparin is an anticoagulant (blood thinner). It is a type of heparin. Another name for enoxaparin is Lovenox®. Enoxaparin is used to prevent or treat blood clots.

How is enoxaparin given?

Enoxaparin is given by injection, every 12 hours. It is injected into the layer of fatty tissue, just under the skin (subcutaneous). Enoxaparin may come in a pre-filled syringe, or you may have to draw it up from a vial.

How do we know that the enoxaparin is working?

Your child or teen may have a blood test to make sure the enoxaparin dose is just right. This is an ANTI-XA test, and timing is very important. The test must be done 4-6 hours after an enoxaparin injection. Depending on the test results, we may need to change the dose. 

Important!

Before giving enoxaparin, tell your doctor or pharmacist if your child or teen:

  • Is allergic to enoxaparin, other kinds of heparin, sulfites, or benzyl alcohol;
  • Has any blood clotting problems;
  • Has any condition that increases the risk of bleeding;
  • Has had a low platelet count (a blood clotting problem called thrombocytopenia) after getting heparin in the past;
  • Has any kidney or liver problems.

Are there any side effects?

Your child or teen may have some of these side effects while taking enoxaparin:

  • Irritation, pain, or redness at the injection site;
  • Longer or heavier menstrual periods (for older girls);
  • Bleeding or bruising more easily than usual (for example, nose bleeds, or bleeding from gums).

Call 911 if your child or teen:

  • Has signs of a life-threatening allergic reaction (wheezing, shortness of breath, chest tightness or chest pain, fever, itching, bad cough, blue skin colour, swelling of face, lips, tongue, or throat).

Call your Case Manager right away, if your child or teen:

  • Develops a rash.
  • Has a bad fall. This is even more important if there is a hit to the head.
  • Gets a deep, dark purple bruise, pain, or swelling at the injection site.
  • Has unusual bleeding (for example: a very long nosebleed, blood in the urine, coughing or throwing up blood, bleeding at the place of injection, bleeding or oozing from a surgical incision).
  • Passes black, sticky, tarry stools or stools with red streaks.

During evenings or weekends, call the Hematologist/Oncologist on-call. Numbers are at the bottom of this page.

Preventing problems when your child or teen is on enoxaparin

Enoxaparin changes how the blood clots. This can increase the risk of bleeding from an injury or surgery. You can prevent problems, or catch them early by:

  • Talking to your doctor right away if your child or teen has a bad fall. This is even more important if there is a hit to the head.
  • Making sure your child or teen wears a helmet for cycling, skateboarding and rollerblading. Do not let your child or teen play contact sports like hockey, downhill skiing, snowboarding, rugby or football. Talk with your doctor about which activities are OK for your child or teen.
  • Tell doctors, dentist and surgeons that your child or teen takes enoxaparin.
  • Call your case manager or doctor before your child or teen has dental work, surgery, medical procedures or immunizations. You may need to hold 1 or 2 doses of enoxaparin before these treatments or tests.
  • Talk with your doctor and pharmacist before giving your child or teen any other medicines that can increase the chance of bleeding. 

Do not use medicines like (Advil®, Motrin®), ASA (Aspirin®), and cold and flu medicines that contain ASA without talking to your doctor or pharmacist. These medications may increase the chance of bleeding. Use acetaminophen (Tylenol®) instead for pain or fever.

How do we store enoxaparin?

  • Enoxaparin multi-dose vials Store these at room temperature in a cool, dry place away from sunlight. Do not store it in the bathroom or kitchen.
  • Enoxaparin pre-filled syringes Keep these in the fridge. They are good in the fridge for 7 days.

Safety first!

  • Do not keep any medicines that are out of date. Check with your pharmacist about the best way to throw away outdated or leftover medicines.
  • Keep enoxaparin locked in a safe place where children can’t see it.
  • Keep a list of all medications your child or teen takes and share this list with your doctor or pharmacist.
  • Do not share your child’s medicine with others. Do not give anyone else’s medicine to your child.

How to reach us

  • Medical Day Unit (MDU) is open weekdays from 8:00 am – 4:30 pm 613-737-7600 x 2470
  • For Urgent Needs during evenings, weekends or holidays, Call the Hematologist/Oncologist on call: 613-737-7600 then press `0` for operator.
  • Ask the operator to page the Hematologist – Oncologist on call. Please don't hang up. It can sometimes take 5 – 10 minutes for the Hematologist Oncologist to reach the operator.
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